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Azithromycin is an antibiotic that fights bacteria. Azithromycin is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, and sexually transmitted diseases.
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The case report is published in the New England Journal of Medicine.
"The case is novel," co-author Dr. David G. Daley told Medscape Medical News. "In a lot of ways, this is our first attempt to test if it's practical."
Daley and colleagues analyzed a retrospective chart of 17,929 patients who received a single oral dose of azithromycin within two weeks the onset of fever. buy azithromycin online australia these patients, 5,890 (41%) were found to have received concurrent therapy drugstore delivery to uk (i.e., other antibiotics or fever medications). The patients were analyzed separately, and the duration of therapy among patients who had concurrent therapy was reported.
Overall, the frequency of concurrent therapy was low (5%–7%). Among patients who were taking concurrent therapy, the median duration of therapy was 11 days (IQR, 2–21 days).
"Most of these patients had azithromycin but did not have concurrent therapy," Daley said. "That tells us that azithromycin alone is not a good choice, and the patient may not be benefiting from the antibiotics by taking one at the same time."
In the majority of patients who didn't receive concurrent therapy, azithromycin was not effective at relieving fever. However, when administered as an intramuscular injection, azithromycin alone was as effective or more than the other antibiotics at relieving fever, regardless of the duration therapy.
The investigators also found that, in this patient population, the incidence of diarrhea significantly increased at the time of azithromycin-alone therapy, possibly as a consequence of decreased oral tolerance.
Daley said this information could have implications for the use of azithromycin as a single dose for treatment of uncomplicated infections.
"It's not a panacea," Daley cautioned. "There will always be cases of people who could use it and aren't getting it, even when there are patients using it, there's always a small number of them who have serious diarrhea. We don't encourage the use of this drug for that reason, but it's worth exploring for those patients. If you want to use it for a single dose, it's helpful, but you should look at Azithromycin 60 Pills 350mg $129 - $2.15 Per pill it as a last resort."
He said this information would likely need to come from randomized clinical trials, and this trial is looking specifically at the patient population in a pediatric specialty practice.
He pointed out that patients with complex cases may receive multiple courses of azithromycin, which could present new risks and complications.
"We don't know how long azithromycin is going to work for individual patients under these adverse conditions," he added. "The point of this study was to see if we could actually find the benefit in a pediatric population, which may or not be important in the setting of multiple antibiotic courses."
Further study would be needed to evaluate the optimal dosage of azithromycin, and also the safety of buy 1g azithromycin online doses administered.
"This does not mean you have to get multiple courses of azithromycin," Daley concluded. "This study shows you should use it as an alternative to use when other antibiotics fail. We think it's important to understand the full spectrum of possible uses, Sildenafil kaufen niederlande and azithromycin is just one option," he said.
This study was supported by the National Institutes of Health's Center for Advancing Translational Sciences and the American Foundation for Prevention of Infectious Diseases (grants MOP-11010004 and F32-AM16-9010; grant 6U01AI027456 from the National Institute of Mental Health). Dr. Daley has disclosed receiving research support from the National Institute of Infectious Diseases through the Institute of Mental Health (R01AI075456-01A1; R01AI066809-01A1; and R01AI082890-01A1). Dr. Daley is also a consultant to Medtronic.
Reviewed by Robert Jasmer, MD Associate Clinical Professor of Medicine, University California, San Francisco and Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner
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Azithromycin and ciprofloxacin for gonorrhea in primary care
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